Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
Abstract
Sequencing of multiple related species followed by comparative genomics analysis constitutes a powerful approach for the systematic understanding of any genome. Here, we use the genomes of 12 Drosophila species for the de novo discovery of functional elements in the fly. Each type of functional element shows characteristic patterns of change, or 'evolutionary signatures', dictated by its precise selective constraints. Such signatures enable...
Paper Details
Title
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
Published Date
Nov 8, 2007
Journal
Volume
450
Issue
7167
Pages
219 - 232
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