E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.

Volume: 17, Issue: 8, Pages: 4782 - 4791
Published: Aug 1, 1997
Abstract
The E2A gene products, E12 and E47, are critical for proper early B-cell development and commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte development. Loss of E2A activity results in a partial block at the earliest stage of T-lineage development. This early T-cell phenotype precedes the development of a T-cell lymphoma which occurs between 3 and 9 months of age. The thymomas are monoclonal and highly malignant...
Paper Details
Title
E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas.
Published Date
Aug 1, 1997
Volume
17
Issue
8
Pages
4782 - 4791
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