Reduced VLDL clearance in ApoeNpc1 mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels
Abstract
Niemann-Pick type C1 (NPC1) promotes the transport of LDL receptor (LDL-R)-derived cholesterol from late endosomes/lysosomes to other cellular compartments. NPC1-deficient cells showed impaired regulation of liver_X receptor (LXR) and sterol regulatory element-binding protein (SREBP) target genes. We observed that Apoe−/−Npc1−/− mice displayed a marked increase in total plasma cholesterol mainly due to increased VLDL, reflecting decreased...
Paper Details
Title
Reduced VLDL clearance in ApoeNpc1 mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels
Published Date
Sep 1, 2010
Journal
Volume
51
Issue
9
Pages
2655 - 2663
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