Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms
Abstract
Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular dystrophy. Using conditional gene targeting in mice, we show that plectin deficiency results in progressive degenerative alterations in striated muscle, including aggregation and partial loss of intermediate filament (IF) networks, detachment of the contractile apparatus from the sarcolemma, profound changes in myofiber costameric cytoarchitecture, and...
Paper Details
Title
Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms
Published Date
May 19, 2008
Journal
Volume
181
Issue
4
Pages
667 - 681
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