Inactivation of specific β cell transcription factors in type 2 diabetes

Volume: 123, Issue: 8, Pages: 3305 - 3316
Published: Aug 1, 2013
Abstract
Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance. Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative stress, a condition associated with β cell dysfunction in both type 1 diabetes (T1DM) and T2DM. Hydrogen peroxide treatment of β cell lines induced cytoplasmic translocation of MAFA and NKX6.1. In parallel, the ability of nuclear PDX1 to bind endogenous target gene...
Paper Details
Title
Inactivation of specific β cell transcription factors in type 2 diabetes
Published Date
Aug 1, 2013
Volume
123
Issue
8
Pages
3305 - 3316
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