Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury
Abstract
Promotion of endogenous β-cell mass expansion could facilitate regeneration in patients with diabetes. We discovered that the secreted protein CTGF (aka CCN2) promotes adult β-cell replication and mass regeneration after injury via increasing β-cell immaturity and shortening the replicative refractory period. However, the mechanism of CTGF-mediated β-cell proliferation is unknown. Here we focused on whether CTGF alters cells of the immune system...
Paper Details
Title
Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury
Published Date
Aug 1, 2015
Journal
Volume
4
Issue
8
Pages
584 - 591
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