Angiotensin type 1 receptor mediates renal production and conversion of prostaglandins E2to F2α in conscious diabetic rats
Volume: 16, Issue: 4, Pages: 774 - 779
Published: Jul 20, 2015
Abstract
Previous studies demonstrated that stimulation of angiotensin subtype 1 receptor (AT1R) led to increased renal generation of prostaglandins E2 (PGE2) and renal inflammation. In turn, PGE2 increases AT1R activity. The conversion of PGE2 to the less active metabolite prostaglandin F2α (PGF2α) via 9-ketoreductase interrupts this feedback loop. The effects of diabetes on the interface between AT1R, PGE2 and PGF2α are not well established. We...
Paper Details
Title
Angiotensin type 1 receptor mediates renal production and conversion of prostaglandins E2to F2α in conscious diabetic rats
Published Date
Jul 20, 2015
Volume
16
Issue
4
Pages
774 - 779
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