Farnesyltransferase Inhibitors: A Comprehensive Review Based on Quantitative Structural Analysis
Abstract
Farnesyltransferase inhibitors (FTIs) have mainly been used in cancer therapy. However, more recently, investigations on these inhibitors revealed that FTIs can be used for the treatment of other diseases such as Progeria, P. falciparum resistant malaria, Trypnosomatid, etc. Hence the development of novel FTIs is an important task for the drug discovery program. Initially, numerous peptidomimetic FTIs were developed from the template of CAAX...
Paper Details
Title
Farnesyltransferase Inhibitors: A Comprehensive Review Based on Quantitative Structural Analysis
Published Date
Nov 1, 2013
Journal
Volume
20
Issue
38
Pages
4888 - 4923
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