Early cerebral small vessel disease and brain volume, cognition, and gait

Decline in cognitive function begins by the 40s, and may be related to future dementia risk. We used data from a community-representative study to determine whether there are age-related differences in simple cognitive and gait tests by the 40s, and whether these differences were associated with covert cerebrovascular disease on magnetic resonance imaging (MRI).Between 2010 and 2012, 803 participants aged 40 to 75 years in the Prospective Urban...