Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function
Abstract
We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions.We studied intercalated discs of HL-1 cardiomyocytes by immunostaining of desmoglein-2 and N-cadherin. Cohesion was measured using a liberase-based...
Paper Details
Title
Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function
Published Date
Sep 11, 2014
Journal
Volume
104
Issue
2
Pages
245 - 257
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