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Antioxidant, Antiproliferative, and Antiangiogenesis Effects of Polyphenol-Rich Seaweed (Sargassum muticum)

Published on Jan 1, 2013in BioMed Research International2.20
· DOI :10.1155/2013/604787
Farideh Namvar19
Estimated H-index: 19
(UPM: Universiti Putra Malaysia),
Rosfarizan Mohamad21
Estimated H-index: 21
+ 3 AuthorsHeshu Sulaiman Rahman11
Estimated H-index: 11
Abstract
In the present study, we evaluated the effect of brown seaweeds Sargassum muticum methanolic extract (SMME), against MCF-7 and MDA-MB-231 breast cancer cell lines proliferation. This algae extract was also evaluated for reducing activity and total polyphenol content. The MTT assay results indicated that the extracts were cytotoxic against breast cancer cell lines in a dose-dependent manner, with IC50 of 22 μg/ml for MCF-7 and 55 μg/ml for MDA-MB-231 cell lines. The percentages of apoptotic MCF-7-treated cells increased from 13% to 67% by increasing the concentration of the SMME. The antiproliferative efficacy of this algal extract was positively correlated with the total polyphenol contents, suggesting a causal link related to extract content of phenolic acids. Cell cycle analysis showed a significant increase in the accumulation of SMME-treated cells at sub-G1 phase, indicating the induction of apoptosis by SMME. Further apoptosis induction was confirmed by Hoechst 33342 and AO/PI staining. Also SMME implanted in vivo into fertilized chicken eggs induced dose-related antiangiogenic activity in the chorioallantoic membrane (CAM). Our results imply a new insight on the novel function of Sargassum muticum polyphenol-rich seaweed in cancer research by induction of apoptosis, antioxidant, and antiangiogenesis effects.
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  • References (41)
  • Citations (47)
References41
Newest
#1Qianming Yu (SHU: Shanghai University)H-Index: 2
#2Jun Yan (SHU: Shanghai University)H-Index: 1
Last.Zhibi Hu (SHU: Shanghai University)H-Index: 4
view all 8 authors...
#1Fang Liu (Dalian Medical University)H-Index: 1
#2Jia Wang (Dalian Medical University)H-Index: 1
Last.Xiangyang Zou (Dalian Medical University)H-Index: 1
view all 8 authors...
#1Suhaila Mohamed (UPM: Universiti Putra Malaysia)H-Index: 25
#2Siti Nadia Hashim (UPM: Universiti Putra Malaysia)H-Index: 1
Last.Hafeedza Abdul Rahman (UPM: Universiti Putra Malaysia)H-Index: 1
view all 3 authors...
#1Farideh Namvar (IAU: Islamic Azad University)H-Index: 19
#2Suhaila Mohamed (UPM: Universiti Putra Malaysia)H-Index: 25
Last.Fauziah Othman (UPM: Universiti Putra Malaysia)H-Index: 13
view all 7 authors...
#1Keiko Wada (Gidai: Gifu University)H-Index: 16
#2Kozue Nakamura (Gidai: Gifu University)H-Index: 21
Last.Chisato Nagata (Gidai: Gifu University)H-Index: 46
view all 10 authors...
Cited By47
Newest
#1Bhakti Tanna (AcSIR: Academy of Scientific and Innovative Research)H-Index: 3
#2Harshad Brahmbhatt (Central Salt and Marine Chemicals Research Institute)H-Index: 9
Last.Avinash Mishra (AcSIR: Academy of Scientific and Innovative Research)H-Index: 26
view all 0 authors...
#1Sheeja Aravindan (Annamalai University)H-Index: 10
#2Dinesh Babu Somasundaram (University of Oklahoma Health Sciences Center)H-Index: 2
Last.Natarajan Aravindan (University of Oklahoma Health Sciences Center)H-Index: 15
view all 0 authors...
#1Hanaa Ali Hussein (UMT: Universiti Malaysia Terengganu)
#2Habsah Mohamad (UMT: Universiti Malaysia Terengganu)H-Index: 3
Last.Mohd Azmuddin Abdullah (UMT: Universiti Malaysia Terengganu)H-Index: 16
view all 5 authors...
#1Yuan Yu (Ocean University of China)H-Index: 3
#2Le Wang (Ocean University of China)
Last.You-Jin Jeon (Jeju National University)H-Index: 48
view all 9 authors...
#1Thanh Sang VoH-Index: 2
#2Dai Hung NgoH-Index: 2
Last.Se-Kwon Kim (Korea Maritime and Ocean University)H-Index: 1
view all 3 authors...
#1Zahra Sanaeimehr (IAU: Islamic Azad University)H-Index: 1
#2Iraj Javadi (IAU: Islamic Azad University)H-Index: 2
Last.Farideh Namvar (IAU: Islamic Azad University)H-Index: 19
view all 3 authors...
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