Autocrine Stimulation of Cardiac Na + -Ca 2+ Exchanger Currents by Endogenous Endothelin Released by Angiotensin II

Volume: 90, Issue: 4, Pages: 374 - 376
Published: Mar 8, 2002
Abstract
The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na(+)-Ca(2+) exchanger (I(NCX)) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in these actions. I(NCX) was studied in isolation in cat cardiac myocytes. Angiotensin II (Ang II) (100 nmol/L) increased I(NCX) at potentials higher than 0 mV (at +60 mV: 2.07 +/- 0.22 pA/pF in control versus 2.73...
Paper Details
Title
Autocrine Stimulation of Cardiac Na + -Ca 2+ Exchanger Currents by Endogenous Endothelin Released by Angiotensin II
Published Date
Mar 8, 2002
Volume
90
Issue
4
Pages
374 - 376
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