Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
Abstract
A hallmark of protein kinase/phosphatase cascades, including mitogen-activated protein kinase (MAPK) pathways, is the spatial separation of their components within cells. The top-level kinase, MAP3K, is phosphorylated at the cell membrane, and cytoplasmic kinases at sequential downstream levels (MAP2K and MAPK) spread the signal to distant targets. Given measured protein diffusivity and phosphatase activities, signal propagation by diffusion...
Paper Details
Title
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
Published Date
Jan 1, 2006
Journal
Volume
2
Issue
1
Pages
61 - 61
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