Development of Growth Hormone Secretagogues
Abstract
The GH secretagogues (GHS) were developed by reverse pharmacology. The objective was to develop small molecules with pharmacokinetics suitable for once-daily oral administration that would rejuvenate the GH/IGF-I axis. Neither the receptor nor the ligand that controlled pulse amplitude of hormone release was known; therefore, identification of lead structures was based on function. I reasoned that GH pulse amplitude could be increased by four...
Paper Details
Title
Development of Growth Hormone Secretagogues
Published Date
Apr 6, 2005
Journal
Volume
26
Issue
3
Pages
346 - 360
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Notes
History