Epithelial–Mesenchymal Transition in Lung Cancer

Over the last several years, epithelial-mesenchymal transition (EMT), a process in which cells undergo a switch from an epithelial phenotype to a mesenchymal phenotype, has emerged as important not only in embryonic development, but also as a potential mechanism for cancer progression. Epithelial cells are characterized by cell-cell interactions, with the formation of tight junctions, lateral, apical, and basal membranes, polarized distribution...