Metabolic rescue in pluripotent cells from patients with mtDNA disease

Nature64.80
Volume: 524, Issue: 7564, Pages: 234 - 238
Published: Jul 15, 2015
Abstract
Mitochondria have a major role in energy production via oxidative phosphorylation, which is dependent on the expression of critical genes encoded by mitochondrial (mt)DNA. Mutations in mtDNA can cause fatal or severely debilitating disorders with limited treatment options. Clinical manifestations vary based on mutation type and heteroplasmy (that is, the relative levels of mutant and wild-type mtDNA within each cell). Here we generated...
Paper Details
Title
Metabolic rescue in pluripotent cells from patients with mtDNA disease
Published Date
Jul 15, 2015
Journal
Volume
524
Issue
7564
Pages
234 - 238
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