Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma
Abstract
Tumor recurrence is a leading cause of cancer mortality. Therapies for recurrent disease may fail, at least in part, because the genomic alterations driving the growth of recurrences are distinct from those in the initial tumor. To explore this hypothesis, we sequenced the exomes of 23 initial low-grade gliomas and recurrent tumors resected from the same patients. In 43% of cases, at least half of the mutations in the initial tumor were...
Paper Details
Title
Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma
Published Date
Jan 10, 2014
Journal
Volume
343
Issue
6167
Pages
189 - 193
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