Cryo-electron tomography: The challenge of doing structural biology in situ
Abstract
Electron microscopy played a key role in establishing cell biology as a discipline, by producing fundamental insights into cellular organization and ultrastructure. Many seminal discoveries were made possible by the development of new sample preparation methods and imaging modalities. Recent technical advances include sample vitrification that faithfully preserves molecular structures, three-dimensional imaging by electron tomography, and...
Paper Details
Title
Cryo-electron tomography: The challenge of doing structural biology in situ
Published Date
Aug 5, 2013
Journal
Volume
202
Issue
3
Pages
407 - 419
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History