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High Density Lipoproteins and Arteriosclerosis Role of Cholesterol Efflux and Reverse Cholesterol Transport

Published on Jan 1, 2001in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
· DOI :10.1161/01.ATV.21.1.13
A. von Eckardstein70
Estimated H-index: 70
,
Jerzy-Roch Nofer28
Estimated H-index: 28
,
Gerd Assmann Frcp86
Estimated H-index: 86
Cite
Abstract
Abstract —High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs. Enhancement of cholesterol efflux and of reverse cholesterol transport (RCT) is considered an important target for antiatherosclerotic drug therapy. Levels and composition of HDL subclasses in plasma are regulated by many factors, including apolipoproteins, lipolytic enzymes, lipid transfer proteins, receptors, and cellular transporters. In vitro experiments as well as genetic family and population studies and investigation of transgenic animal models have revealed that HDL cholesterol plasma levels do not necessarily reflect the efficacy and antiatherogenicity of RCT. Instead, the concentration of HDL subclasses, the mobilization of cellular lipids for efflux, and the kinetics of HDL metabolism are important determinants of RCT and the risk of atherosclerosis.
  • References (211)
  • Citations (580)
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References211
Newest
Published on Dec 18, 2001in Circulation23.05
Klaus A. Dugi16
Estimated H-index: 16
,
Karin Brandauer2
Estimated H-index: 2
+ 10 AuthorsHorst Kather1
Estimated H-index: 1
Background— The crucial function of hepatic lipase (HL) in lipid metabolism has been well established, but the relationship between HL activity and coronary artery disease (CAD) is disputed. Methods and Results— We measured HL activity in the postheparin plasma of 200 consecutive men undergoing elective coronary angiography and determined the degree of CAD with the extent score, which has been shown to be better correlated with known risk factors than other measures of CAD extent. We found a sig...
Published on Jan 1, 1995
R Charles Scriver1
Estimated H-index: 1
I. INTRODUCTION II. PERSPECTIVES III. GENERAL THEMES IV. CANCER V. CHROMOSOMES VI. DIAGNOSTIC APPROACHES VII. CARBOHYDRATES VIII. AMINO ACIDS IX. ORGANIC ACIDS X. DISORDERS OF MITOCHONDRIAL FUNCTION XI. PURINES AND PYRIMIDINES XII. LIPIDS XIII. PORPHYRINS XIV. METALS XV. PEROXISOMES XVI. LYSOSOMAL DISORDERS XVII. VITAMINS XVIII. HORMONES XIX. BLOOD XX. IMMUNE AND DEFENSE SYSTEMS XXI. MEMBRANE TRANSPORT DISORDERS XXII. CONNECTIVE TISSUE XXIII. CARDIOVASCULAR SYSTEM XXIV. KIDNEY XXV. MUSCLE XXVI. ...
Published on Dec 1, 2000in Biochemistry2.95
Nofer2
Estimated H-index: 2
,
Manfred Fobker34
Estimated H-index: 34
+ 9 Authorsvon Eckardstein A2
Estimated H-index: 2
Our earlier studies demonstrated that high-density lipoproteins (HDLs) stimulate multiple signaling pathways, including activation of phosphatidylcholine-specific phospholipases C and D (PC-PLs) and phosphatidylinositol-specific phospholipase C (PI-PLC). However, only activation of PC-PLs was linked to the HDL-induced cholesterol efflux. In the study presented here, the role of HDL-induced PI-PLC activation was studied. In human skin fibroblasts, HDL potently induced PI-PLC as inferred from enha...
Published on Nov 3, 2000in Journal of Biological Chemistry
John F. Oram57
Estimated H-index: 57
(UW: University of Washington),
Richard M. Lawn60
Estimated H-index: 60
(UW: University of Washington)
+ 1 AuthorsDavid Wade10
Estimated H-index: 10
(UW: University of Washington)
Abstract Lipid-poor high density lipoprotein apolipoproteins remove cholesterol and phospholipids from cells by an active secretory pathway controlled by an ABC transporter called ABCA1. This pathway is induced by cholesterol and cAMP analogs in a cell-specific manner. Here we provide evidence that increased plasma membrane ABCA1 accounts for the enhanced apolipoprotein-mediated lipid secretion from macrophages induced by cAMP analogs. Treatment of RAW264 macrophages with 8-bromo-cAMP caused par...
Published on Nov 1, 2000in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
Anne Tailleux32
Estimated H-index: 32
(Rhône-Poulenc),
Muriel Bouly1
Estimated H-index: 1
(Rhône-Poulenc)
+ 7 AuthorsCatherine Fievet43
Estimated H-index: 43
(Rhône-Poulenc)
Abstract —Studies performed in vivo have been controversial regarding the implication of human apolipoprotein (apo)A-II in the atherogenic process. Expression of human apoA-II in transgenic mice fed a chow diet leads to (1) a bimodal distribution of high density lipoprotein (HDL) size as in humans, (2) a reduction in total cholesterol concentration that is mainly due to a reduction in non–HDL cholesterol level, and (3) a dramatic reduction in mouse endogenous apoA-I and apoA-II. After 20 weeks o...
Published on Oct 20, 2000in Journal of Biological Chemistry
Nan Wang50
Estimated H-index: 50
(Columbia University),
David L. Silver29
Estimated H-index: 29
(Columbia University)
+ 1 AuthorsAlan R. Tall111
Estimated H-index: 111
(Columbia University)
Abstract Mutations of the ABC1 transporter have been identified as the defect in Tangier disease, characterized by low HDL and cholesterol ester accumulation in macrophages. A full-length mouse ABC1 cDNA was used to investigate the mechanisms of lipid efflux to apoA-I or HDL in transfected 293 cells. ABC1 expression markedly increased cellular cholesterol and phospholipid efflux to apoA-I but had only minor effects on lipid efflux to HDL. The increased lipid efflux appears to involve a direct in...
Published on Sep 15, 2000in Journal of Biological Chemistry
Anna E. Bortnick2
Estimated H-index: 2
(Children's Hospital of Philadelphia),
George H. Rothblat76
Estimated H-index: 76
(Children's Hospital of Philadelphia)
+ 4 AuthorsOmar L. Francone1
Estimated H-index: 1
(Children's Hospital of Philadelphia)
Abstract Studies show that lipid-free apoA-I stimulates release of cholesterol and phospholipid from fibroblasts and macrophages. ATP-binding cassette 1 (ABC1) is implicated in this release and has been identified as the genetic defect in Tangier disease, evidence that ABC1 is critical to the biogenesis of high density lipoprotein. We quantified levels of ABC1 mRNA, protein, and cholesterol efflux from J774 mouse macrophages ± exposure to a cAMP analog. Up-regulating ABC1 mRNA correlated to incr...
Published on Sep 1, 2000in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
Charles W. Rittershaus8
Estimated H-index: 8
(BMC: Boston Medical Center),
David P. Miller1
Estimated H-index: 1
(BMC: Boston Medical Center)
+ 10 AuthorsDavid T. Beattie3
Estimated H-index: 3
(BMC: Boston Medical Center)
Abstract —Using a vaccine approach, we immunized New Zealand White rabbits with a peptide containing a region of cholesteryl ester transfer protein (CETP) known to be required for neutral lipid transfer function. These rabbits had significantly reduced plasma CETP activity and an altered lipoprotein profile. In a cholesterol-fed rabbit model of atherosclerosis, the fraction of plasma cholesterol in HDL was 42% higher and the fraction of plasma cholesterol in LDL was 24% lower in the CETP-vaccina...
Published on Sep 1, 2000in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
M. N. Nanjee4
Estimated H-index: 4
(PAN: Polish Academy of Sciences),
C. J. Cooke4
Estimated H-index: 4
(PAN: Polish Academy of Sciences)
+ 1 AuthorsN. E. Miller1
Estimated H-index: 1
(PAN: Polish Academy of Sciences)
Abstract —When cultured cells are exposed to plasma, the initial acceptors of unesterified cholesterol are small lipid-poor apolipoprotein A-I (apoA-I)–containing high density lipoproteins (HDLs) with pre-β electrophoretic mobility. These are converted by lecithin:cholesterol acyltransferase into larger spheroidal cholesteryl ester–rich HDLs with α mobility. To study the determinants of the concentration of small pre-β HDLs in tissue fluids, we collected prenodal peripheral lymph from 34 fasted ...
Cited By580
Newest
Published on 2019in Frontiers in Endocrinology3.63
Sira Karvinen4
Estimated H-index: 4
(University of Jyväskylä),
Matthew Jergenson1
Estimated H-index: 1
(UMN: University of Minnesota)
+ 6 AuthorsEija K. Laakkonen4
Estimated H-index: 4
(University of Jyväskylä)
Cardiovascular disease (CVD) is the primary cause of mortality in women in developed countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that occurs after the onset of menopause. This observation suggests the presence of factors in the middle-aged women that accelerate the progression of CVD independent of chronological aging. Leisure time physical activity (LTPA) is a well-established protective factor against CVD. However, its role in attenuating atherogenic...
Published on 2019in Molecules3.06
Karin Kornmueller3
Estimated H-index: 3
,
Ivan Vidakovic , Ruth Prassl25
Estimated H-index: 25
Lipoproteins are endogenous nanoparticles which are the major transporter of fats and cholesterol in the human body. They play a key role in the regulatory mechanisms of cardiovascular events. Lipoproteins can be modified and manipulated to act as drug delivery systems or nanocarriers for contrast agents. In particular, high density lipoproteins (HDL), which are the smallest class of lipoproteins, can be synthetically engineered either as nascent HDL nanodiscs or spherical HDL nanoparticles. Rec...
Jia Teng Sun3
Estimated H-index: 3
(SJTU: Shanghai Jiao Tong University),
Yuan Yuan Chen (SJTU: Shanghai Jiao Tong University)+ 5 AuthorsYan Liu11
Estimated H-index: 11
(SJTU: Shanghai Jiao Tong University)
Calcific aortic valve disease (CAVD) is characterized by progressive mineralization of the aortic valve. Lipid infiltration and oxidative stress are the driving forces for the initiation and development of this disease. However, it remains unknown whether oxidized high-density lipoprotein (ox-HDL) plays a role in the mineralization of aortic valve interstitial cells (AVICs). Serum ox-HDL levels were determined in 168 severe CAVD patients and 168 age- and gender-matched non-CAVD controls. Results...
Published on May 27, 2019in Biological Chemistry3.01
Mohsen Khosravi1
Estimated H-index: 1
,
Adeleh Poursaleh + 2 AuthorsMohammad Najafi1
Estimated H-index: 1
Published on May 7, 2019in Frontiers in Aging Neuroscience3.63
Nathan F. Johnson12
Estimated H-index: 12
(UK: University of Kentucky),
Brian T. Gold27
Estimated H-index: 27
(UK: University of Kentucky)
+ 5 AuthorsDavid K. Powell16
Estimated H-index: 16
(UK: University of Kentucky)
A growing body of evidence indicates that biomarkers of cardiovascular risk may be related to cerebral health. However, little is known about the role non-fasting lipoprotein play in assessing age-related declines in a cerebral biomarker sensitive to vascular compromise, white matter (WM) microstructure. High-density lipoprotein cholesterol (HDL-C) is atheroprotective and low-density lipoprotein cholesterol (LDL-C) is a major atherogenic lipoprotein. This study explored the relationships between...
Tian-Yu Zhao , Song Lei1
Estimated H-index: 1
+ 7 AuthorsLiangwen Xu2
Estimated H-index: 2
Coronary artery disease has become a major health concern over the past several decades. We aimed to explore the association of single nucleotide polymorphisms (SNPs) in the ATP-binding cassette subfamily A member 1 (ABCA1) and lifestyle factors with coronary artery disease (CAD) in dyslipidemia. This nested case-control study included 173 patients with CAD and 500 matched control individuals (1:3, case: control) from a district in southern China. We collected medical reports, lifestyle details,...
Published on Mar 1, 2019in Gene2.64
Si-Qi Shen (Peking Union Medical College Hospital), Xiao-Wei Yan (Peking Union Medical College Hospital)+ 1 AuthorsXiao-Hui Ji
Abstract Aims The previous studies on ABCG1 using genetically modified mice showed inconsistent results on atherosclerosis. The aim of this study was to determine whether accurate target knockout of ABCG1 would result in transcriptional changes of other atherosclerosis-related genes. Methods ABCG1 knockout mouse model was obtained by precise gene targeting without affecting non-target DNA sequences in C57BL/6 background. The wildtype C57BL/6 mice were regarded as control group. 12-week-old male ...
Ina Vernikouskaya4
Estimated H-index: 4
(University of Ulm),
Alexander Pochert5
Estimated H-index: 5
(University of Ulm)
+ 1 AuthorsVolker Rasche27
Estimated H-index: 27
(University of Ulm)
Objectives A common limitation of all 1H contrast agents is that they only allow indirect visualization through modification of the intrinsic properties of the tissue, making quantification of this effect challenging. 19F compounds, on the contrary, are measured directly, without any background signal. There is a linear relationship between the amount of 19F spins and the intensity of the signal. However, non-uniformity of the radiofrequency field may lead to errors in the quantified 19F signal ...
View next paperTangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1