The identification of microRNAs in a genomically unstable region of human chromosome 8q24.
Abstract
The PVT1 locus is identified as a cluster of T(2;8) and T(8;22) null MYC-activating chromosomal translocation breakpoints extending 400 kb downstream of MYC in a subset (approximately 20%) of Burkitt's lymphoma (vBL). Recent reports that microRNAs (miRNA) may be associated with fragile sites and cancer-associated genomic regions prompted us to investigate whether the PVT1 region on chromosome 8q24 may contain miRNAs. Computational analysis of...
Paper Details
Title
The identification of microRNAs in a genomically unstable region of human chromosome 8q24.
Published Date
Feb 1, 2008
Journal
Volume
6
Issue
2
Pages
212 - 221
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History