Charge and Hydrophobicity Effects of NIR Fluorophores on Bone-Specific Imaging
Abstract
Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared...
Paper Details
Title
Charge and Hydrophobicity Effects of NIR Fluorophores on Bone-Specific Imaging
Published Date
Jan 1, 2015
Journal
Volume
5
Issue
6
Pages
609 - 617
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