Original paper

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

Volume: 120, Issue: 12, Pages: 4388 - 4398
Published: Dec 1, 2010
Abstract
During the classic "fight-or-flight" stress response, sympathetic nervous system activation leads to catecholamine release, which increases heart rate and contractility, resulting in enhanced cardiac output. Catecholamines bind to β-adrenergic receptors, causing cAMP generation and activation of PKA, which phosphorylates multiple targets in cardiac muscle, including the cardiac ryanodine receptor/calcium release channel (RyR2) required for...
Paper Details
Title
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice
Published Date
Dec 1, 2010
Volume
120
Issue
12
Pages
4388 - 4398
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