Three-dimensional co-culture facilitates the differentiation of embryonic stem cells into mature cardiomyocytes.

Volume: 112, Issue: 12, Pages: 3555 - 3562
Published: Dec 1, 2011
Abstract
The cardiomyocyte (CM) differentiation of embryonic stem cells (ESCs) is routinely cultured as two-dimensional (2D) monolayer, which doesn't mimic in vivo physiological environment and may lead to low differentiated level of ESCs. Here, we develop a novel strategy that enhances CM differentiation of ESCs in collagen matrix three-dimensional (3D) culture combined with indirect cardiac fibroblasts co-culture. ESCs were cultured in hanging drops to...
Paper Details
Title
Three-dimensional co-culture facilitates the differentiation of embryonic stem cells into mature cardiomyocytes.
Published Date
Dec 1, 2011
Volume
112
Issue
12
Pages
3555 - 3562
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