Technical approaches for mouse models of human disease
Abstract
The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain desired gene mutations by using the following processes: targeted mutations that eliminate function in the whole organism or in a specific tissue; forward genetic screens using chemicals or transposons; or the introduction of exogenous transgenes...
Paper Details
Title
Technical approaches for mouse models of human disease
Published Date
May 1, 2011
Journal
Volume
4
Issue
3
Pages
305 - 310
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Notes
History