Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System

The amyloid hypothesis predicts that increased production or decreased clearance of β-amyloid (Aβ) leads to amyloidosis, which ultimately culminates in Alzheimer disease (AD).To investigate whether dynamic changes in Aβ levels in the human central nervous system may be altered by aging or by the pathology of AD and thus contribute to the risk of AD.Repeated-measures case-control study.Washington University School of Medicine in St Louis,...