On-line Microdialysis Coupled with Liquid Chromatography for Biomedical Analysis

This work presents a review of the microdialysis (MD) sampling technique for on-line coupling with high-performance liquid chromatography (HPLC) for biomedical analysis. MD-HPLC was first used in the field of brain metabolism to study neurotransmission, and this remains its common application in the biomedical field. On-line MD-HPLC hyphenated methods provide advantages over those with off-line MD-based techniques, including simplified sample...