β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Volume: 52, Issue: 1, Pages: 102 - 110
Published: Jan 1, 2003
Abstract
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in beta-cell mass contributes to this. We examined pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m(2); 41 with type 2 diabetes, 15 with impaired fasting glucose [IFG], and 35 nondiabetic subjects) and 33 lean cases (BMI <25 kg/m(2); 16 type 2 diabetic and 17 nondiabetic subjects). We measured relative beta-cell...
Paper Details
Title
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Published Date
Jan 1, 2003
Journal
Volume
52
Issue
1
Pages
102 - 110
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