Mechanism for Prevention of Alcohol-Induced Liver Injury by Dietary Methyl Donors
Abstract
Alcohol-induced liver injury (ALI) has been associated with, among other molecular changes, abnormal hepatic methionine metabolism, resulting in decreased levels of S-adenosylmethionine (SAM). Dietary methyl donor supplements such as SAM and betaine mitigate ALI in animal models; however, the mechanisms of protection remain elusive. It has been suggested that methyl donors may act via attenuation of alcohol-induced oxidative stress. We...
Paper Details
Title
Mechanism for Prevention of Alcohol-Induced Liver Injury by Dietary Methyl Donors
Published Date
Jan 29, 2010
Journal
Volume
115
Issue
1
Pages
131 - 139
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