Hyperinsulinemia is Associated with Increased Soluble Insulin Receptors Release from Hepatocytes
Abstract
It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (SIR) has been found elevated in patients with diabetes mellitus. We explored if insulin binds to SIRs in circulation under...
Paper Details
Title
Hyperinsulinemia is Associated with Increased Soluble Insulin Receptors Release from Hepatocytes
Published Date
Jun 19, 2014
Journal
Volume
5
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