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Predictors of abdominal obesity and high susceptibility of cardiometabolic risk to its increments among Turkish women: a prospective population-based study.

Published on Mar 1, 2007in Metabolism-clinical and Experimental6.51
· DOI :10.1016/j.metabol.2006.10.016
Altan Onat42
Estimated H-index: 42
(Istanbul University),
Ibrahim Sari21
Estimated H-index: 21
+ 4 AuthorsVedat Sansoy23
Estimated H-index: 23
(Istanbul University)
Cite
Abstract
Abstract To investigate determinants of abdominal obesity and its metabolic and clinical consequences relative to its degree in women, a prospective evaluation of 1682 female participants (aged 28-79 years at baseline), representative of Turkey's women, was performed. For components of metabolic syndrome (MS), criteria of National Cholesterol Education Program guidelines were adopted, modified for cut point of 91 cm or greater for abdominal obesity and less than 45 mg/dL for low high-density lipoprotein (HDL) cholesterol. Fasting insulin and C-reactive protein concentrations and (inversely) smoking more than 10 cigarettes daily were significant predictors of newly developed abdominal obesity at a follow-up of mean 5.9 years. In the prediction of high triglyceride–low HDL dyslipidemia, elevated blood pressure (BP) or MS and doubling of baseline fasting insulin level contributed approximately 25% to the hazard ratio (HR), whereas waist circumference exhibited independent HRs of 1.30, 1.62, and 2.22, respectively. Waist girth (or body mass index) quartiles was the major predictor (HR, 1.72) of diabetes mellitus (DM), followed by physical inactivity and total cholesterol and insulin levels, all independent of each other. Waist girth quartiles in women conferred excess risk of incident coronary heart disease from quartile II onward, independent of age, DM, and elevated BP. Fasting insulin and C-reactive protein levels and (inversely) heavy smoking are main predictors in Turkish women of abdominal obesity. Across waist girth quartiles, multiadjusted relative risks for dyslipidemia, elevated BP, MS, and coronary heart disease rise sharply and asymptotically from quartile II (≥83 cm) onward, whereas risk of DM emerges in the top quartile. A waist girth of 83 cm or greater should be regarded as abdominal obesity among Turkish women.
  • References (30)
  • Citations (42)
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References30
Newest
Published on Apr 1, 2006in Metabolism-clinical and Experimental6.51
Altan Onat42
Estimated H-index: 42
(Istanbul University),
Gülay Hergenç28
Estimated H-index: 28
(YTU: Yıldız Technical University)
+ 3 AuthorsGünay Can31
Estimated H-index: 31
(Istanbul University)
The aims of this study were to investigate the extent of concordance between metabolic syndrome (MS) and insulin resistance (IR), the features of discordance, and the magnitude of their independent association with cardiovascular disease (CVD) risk. After exclusion of individuals with diabetes and impaired fasting glucose, the population sample of 1534 men and women, representative of Turkish adults (mean age, 52.2 years), were evaluated cross-sectionally and at a mean 2 years' follow-up. Metabo...
Published on Jan 1, 2006in International Journal of Obesity4.51
Anoop Misra51
Estimated H-index: 51
(AIIMS: All India Institute of Medical Sciences),
Naval Kishore Vikram17
Estimated H-index: 17
(AIIMS: All India Institute of Medical Sciences)
+ 3 AuthorsV P Gupta1
Estimated H-index: 1
(University of Rajasthan)
Waist circumference cutoff points and action levels for Asian Indians for identification of abdominal obesity
Published on Sep 1, 2005in The Lancet59.10
K. George M.M. Alberti33
Estimated H-index: 33
,
Paul Zimmet108
Estimated H-index: 108
,
Jonathan E. Shaw90
Estimated H-index: 90
Published on Jun 1, 2005in International Journal of Obesity4.51
Fahad Razak18
Estimated H-index: 18
(Population Health Research Institute),
Sonia S. Anand74
Estimated H-index: 74
(Population Health Research Institute)
+ 4 AuthorsSalim Yusuf Mb Bs DPhil Frcpc209
Estimated H-index: 209
(Population Health Research Institute)
To evaluate whether body mass index (BMI) and other anthropometric indices of visceral obesity vary by ethnic group in their distribution and their relationship to metabolic abnormalities. Cross-sectional study. Canadian men and women, aged 35–75 years, of South Asian (n=342), Chinese (n=317), European (n=326) and Aboriginal (n=301) descent were recruited using stratified random sampling. Anthropometric indices (BMI, waist to hip ratio (WHR) and waist circumference (WC)), metabolic markers (fast...
Published on Feb 24, 2005in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
Nobukazu Ishizaka34
Estimated H-index: 34
(UTokyo: University of Tokyo),
Yuko Ishizaka23
Estimated H-index: 23
(UTokyo: University of Tokyo)
+ 2 AuthorsMinoru Yamakado7
Estimated H-index: 7
(UTokyo: University of Tokyo)
Objective— There are few data available on possible independent association between uric acid and carotid atherosclerosis. Here we first sought to investigate association between uric acid levels and metabolic syndrome in Japanese; second, we assessed whether there is an independent association of uric acid with prevalence of carotid atherosclerosis in individuals subdivided according to gender and metabolic syndrome status. Methods and Results— Cross-sectional data from 8144 individuals who und...
Published on Jan 1, 2005in American Journal of Cardiology2.84
Diego F. Wyszynski33
Estimated H-index: 33
(BU: Boston University),
Dawn Waterworth56
Estimated H-index: 56
(GSK: GlaxoSmithKline)
+ 13 AuthorsSanjay Sharma10
Estimated H-index: 10
(GSK: GlaxoSmithKline)
Genetic Epidemiology of Metabolic Syndrome is a multinational, family-based study to explore the genetic basis of the metabolic syndrome. Atherogenic dyslipidemia (defined as low plasma high-density lipoprotein cholesterol with elevated triglycerides ( 75th percentile for age, gender, and country, respectively) identified affected subjects for the metabolic syndrome. This report examines the frequency at which atherogenic dyslipidemia predicts the metabolic syndrome of the National Cholesterol E...
Published on Aug 1, 2004in International Journal of Obesity4.51
Altan Onat42
Estimated H-index: 42
,
Günsel Ş. Avcı3
Estimated H-index: 3
+ 3 AuthorsVedat Sansoy23
Estimated H-index: 23
Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk
Published on Jul 1, 2004in Obesity Research
Cihangir Erem25
Estimated H-index: 25
(Karadeniz Technical University),
Cengiz Arslan1
Estimated H-index: 1
(Karadeniz Technical University)
+ 5 AuthorsMünir Telatar10
Estimated H-index: 10
(Karadeniz Technical University)
Objective: To estimate the prevalence of overweight and obesity (general and central) in the Trabzon Region and its associations with demographic factors (age, sex, marital status, reproductive history in women, and level of education), socioeconomic factors (household income and occupation), family history of selected medical conditions (diabetes, hypertension, and obesity), lifestyle factors (smoking habits, physical activity, and alcohol consumption), and hypertension in the adult population....
Published on May 1, 2004in Obesity Reviews8.19
C Filozof1
Estimated H-index: 1
(Complutense University of Madrid),
M. C. Fernández Pinilla1
Estimated H-index: 1
(Complutense University of Madrid),
A. Fernández‐Cruz1
Estimated H-index: 1
(Complutense University of Madrid)
Summary Cigarette smoking is the single most important preventable cause of death and illness. Smoking cessation is associated with substantial health benefits. Weight gain is cited as a primary reason for not trying to quit smoking. There is a great variability in the amount of weight gain but younger ages, lower socio-economic status and heavier smoking are predictors of higher weight gain. Weight change after smoking cessation appears to be influenced by underlying genetic factors. Besides, w...
Published on Apr 1, 2004in Diabetes & Metabolism4.01
B Balkau1
Estimated H-index: 1
Cited By42
Newest
Published on Dec 1, 2019in BMC Cardiovascular Disorders1.95
Jun Wang (First Affiliated Hospital of Xinjiang Medical University), Xing Li (First Affiliated Hospital of Xinjiang Medical University)+ 5 AuthorsYi-Ning Yang15
Estimated H-index: 15
(First Affiliated Hospital of Xinjiang Medical University)
Background The association between mean platelet volume (MPV) and coronary plaque vulnerability in patients with non-ST-elevation ACS (NSTE-ACS) has not been investigated. We performed a retrospective study to evaluate the association between MPV and plaque vulnerability using optical coherence tomography (OCT).
Published on Jun 3, 2018in Journal of Lipids
Mohamadreza Haeri1
Estimated H-index: 1
(Qom University of Medical Sciences),
Mahmoud Parham5
Estimated H-index: 5
(Qom University of Medical Sciences)
+ 1 AuthorsJamshid Vafaeimanesh1
Estimated H-index: 1
(Qom University of Medical Sciences)
Background. Some studies suggest a significant relationship between Helicobacter pylori infection and atherogenesis; but the mechanism of the relationship is almost unknown. The current study aimed at evaluating the relationship between H. pylori infection and serum lipid profile. Patients and Methods. The current study was conducted on 2573 patients, from 2008 to 2015. The serum anti-Helicobacter pylori antibody titer and serum lipid profile were assessed in the study population; data were stat...
Published on Jan 1, 2016in Journal of Medical Biochemistry2.00
Anna Besedina1
Estimated H-index: 1
BACKGROUND:Coronary heart disease is the leading cause of death and disability worldwide. Hypertension is a major independent risk factor for the development of CHD. Abnormalities in NO generation or activity have been proposed as a major mechanism of CHD. The purpose of this article is to determine the activity of eNOS and iNOS in patients with isolated CHD and CHD associated with HT of different age groups. METHODS:Fifty patients with isolated CHD and 42 patients with CHD associated with HT we...
Published on Apr 1, 2015in The American Journal of Clinical Nutrition6.57
Karina Fischer4
Estimated H-index: 4
,
Daniela Moewes2
Estimated H-index: 2
+ 5 AuthorsUte Nöthlings41
Estimated H-index: 41
BACKGROUND Visceral (VAT) and subcutaneous abdominal (SAAT) and trunk (STRAT) adipose tissue (AT) have been suggested to be differentially influenced by diet. OBJECTIVE We investigated whether and to what extent usual patterns of nutrient intake are associated with VAT, SAAT, and STRAT compared with nondietary predictors in northern German adults (n = 583). DESIGN AT volumes were quantified by magnetic resonance imaging. Nutrient intake was estimated by a 112-item food-frequency questionnaire li...
Published on Oct 1, 2014in American Journal of Biomedical Sciences
Aleksandra S. Kristo1
Estimated H-index: 1
(Cornell University),
Angelos K. Sikalidis1
Estimated H-index: 1
,
Angelos Sikalidis1
Estimated H-index: 1
Cardiovascular disease (CVD) is a chronic disease prevalent both in developing and developed countries. Numerous CVD risk factors associated with nutritional behavior and status in children and adolescents set the stage for adult CVD. A significant body of evidence suggests that there is opportunity for abolishment of at least some of the adverse manifestations of CVD and ability for health improvement if proper nutritional practice is followed during young age. Turkey is a country with a large ...
Published on Jan 1, 2014in World Journal of Gastroenterology3.41
Frank T Wong1
Estimated H-index: 1
,
Erin Rayner-Hartley1
Estimated H-index: 1
,
Michael F. Byrne22
Estimated H-index: 22
Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. pylori. Different conditions associated with H. pylori infection include those from hematologic, cardiopulmonary, metabolic, neurologic, and dermatologic systems. The aim of this article is to provide a concise review of th...
Published on Jan 1, 2014in The Scientific World Journal
Jamshid Vafaeimanesh7
Estimated H-index: 7
,
Seyyed Fakhroldin Hejazi1
Estimated H-index: 1
+ 3 AuthorsMohammadreza Seyyedmajidi3
Estimated H-index: 3
Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG anti...
Published on Jan 1, 2013in Journal of Biomarkers
Milad Abolhalaj1
Estimated H-index: 1
(Tehran University of Medical Sciences),
Mahsa M. Amoli21
Estimated H-index: 21
,
Parvin Amiri11
Estimated H-index: 11
Subject & Aim. Endothelial nitric oxide synthase (eNOS) is one of the most important candidate genes in CAD. A functional polymorphism within eNOS gene is a 27 bp VNTR on its intron 4 which has been shown to be associated with various diseases. In this study we investigated eNOS VNTR polymorphism in addition to eNOS gene expression profile in patients with CAD. Material and Methods. The study comprised patients with angiographically confirmed CAD (CAD
Published on Jan 1, 2013in Archives of Iranian Medicine1.14
Masoumeh Sadeghi21
Estimated H-index: 21
,
Zahra Pourmoghaddas6
Estimated H-index: 6
+ 5 AuthorsNizal Sarrafzadegan41
Estimated H-index: 41
OBJECTIVE: To investigate the association between obesity indices, abdominal fat distribution, and lipid profile in patients with stable angina (SA). METHODS: Body weight, height, waist circumference (WC), body mass index (BMI), and waist /height ratio (WHtR) of 123 patients with SA who underwent coronary angiography were measured. Fasting blood samples were taken to measure the levels of fasting blood sugar (FBS), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C, HDL...
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