Enhanced siRNA delivery using oleic acid derivative of polyethylenimine.
Abstract
RNA interference has promising therapeutic potential. However, safe and efficacious delivery systems are necessary for its application in the clinic.An oleic acid (OA) derivative of branched polyethylenimine (PEI, M.W. 2000 Da), PEI-OA, was synthesized and evaluated for small interfering RNA (siRNA) delivery in SK-HEP-1 liver cancer cells stably transfected with luciferase. The physiochemical properties of PEI-OA/siRNA complexes, their cellular...
Paper Details
Title
Enhanced siRNA delivery using oleic acid derivative of polyethylenimine.
Published Date
Apr 1, 2012
Journal
Volume
32
Issue
4
Pages
1267 - 71
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