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The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study
Published on Oct 1, 2006in Journals of Gerontology Series A-biological Sciences and Medical Sciences 4.90
· DOI :10.1093/gerona/61.10.1059
Bret H. Goodpaster79
Estimated H-index: 79
(University of Pittsburgh),
Seok Won Park18
Estimated H-index: 18
(University of Pittsburgh)
+ 7 AuthorsAnne B. Newman134
Estimated H-index: 134
(University of Pittsburgh)
Abstract
BACKGROUND: The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking. METHODS: Three-year changes in muscle mass and strength were determined in 1880 older adults in the Health, Aging and Body Composition Study. Knee extensor strength was measured by isokinetic dynamometry. Whole body and appendicular lean and fat mass were assessed by dual-energy x-ray absorptiometry and computed tomography. RESULTS: Both men and women lost strength, with men losing almost twice as much strength as women. Blacks lost about 28% more strength than did whites. Annualized rates of leg strength decline (3.4% in white men, 4.1% in black men, 2.6% in white women, and 3.0% in black women) were about three times greater than the rates of loss of leg lean mass ( approximately 1% per year). The loss of lean mass, as well as higher baseline strength, lower baseline leg lean mass, and older age, was independently associated with strength decline in both men and women. However, gain of lean mass was not accompanied by strength maintenance or gain (ss coefficients; men, -0.48 +/- 4.61, p =.92, women, -1.68 +/- 3.57, p =.64). CONCLUSIONS: Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of muscle mass, suggesting a decline in muscle quality. Moreover, maintaining or gaining muscle mass does not prevent aging-associated declines in muscle strength.
  • References (40)
  • Cited By (1157)
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References40
Published on Jun 1, 2002in Aging Clinical and Experimental Research 2.12
Taina Rantanen48
Estimated H-index: 48
,
Kirsten Avlund42
Estimated H-index: 42
+ 3 AuthorsPertti E1
Estimated H-index: 1
177 Citations
Published on Aug 1, 2001in American Journal of Physiology-cell Physiology 3.45
Scott Trappe52
Estimated H-index: 52
(Ball State University),
Michael P. Godard11
Estimated H-index: 11
(Ball State University)
+ 3 AuthorsDavid Porter3
Estimated H-index: 3
(Ball State University)
The purpose of this study was to1) examine single cell contractile mechanics of skeletal muscle before and after 12 wk of progressive resistance training (PRT) in older women (n = 7; 74 ± 2 yr) and 2) to compare these results to our previously completed single cell PRT work with older men (n = 7; 74 ± 2 yr) (Trappe S, Williamson D, Godard M, Porter D, Rowden G, and Costill D. J Applied Physiol 89:143–152, 2000). Knee extensor PRT was performed 3 days/wk at 80% of one-repetition maximum. Muscle b...
145 Citations Source Cite
Published on May 1, 1997in Journal of Nutrition 4.40
Tamara B. Harris103
Estimated H-index: 103
(National Institutes of Health)
74 Citations Source Cite
Published on Dec 1, 1998in Journal of Applied Physiology 3.26
Taina Rantanen48
Estimated H-index: 48
,
K. Masaki1
Estimated H-index: 1
+ 3 AuthorsJack M. Guralnik121
Estimated H-index: 121
The aim of this study was to describe changes in grip strength over a follow-up period of ∼27 yr and to study the associations of rate of strength decline with weight change and chronic conditions. The data are from the Honolulu Heart Program, a prospective population-based study established in 1965. Participants at exam 1 were 8,006 men (ages 45–68 yr) who were of Japanese ancestry and living in Hawaii. At follow-up, 3,741 men (age range, 71–96 yr) participated. Those who died before the follow...
259 Citations Source Cite
Ronenn Roubenoff76
Estimated H-index: 76
Summary Aging causes loss of many of the anabolic signals to muscle that are present in young adulthood. Recent research suggests that there is also an increase in catabolic signals with age. Research in the field of sarcopenia is evolving rapidly, and the process is now recognized as an important cause of frailty and morbidity in the elderly. This review focuses on recent developments in the field, especially regarding the role of catabolic stimuli in causing sarcopenia. There is now an impress...
211 Citations Source Cite
Eleanor Marie Simonsick88
Estimated H-index: 88
(National Institutes of Health),
Anne B. Newman27
Estimated H-index: 27
(National Institutes of Health)
+ 4 AuthorsTamara B. Harris112
Estimated H-index: 112
(National Institutes of Health)
Results. The expanded self-report items identified one half of the men and one third of the women as exceptionally well functioning and 10% to 13% of men and 21% to 36% of women with lower capacity. The supplemented and rescored performance battery discriminated function over the full range. The LDCW further differentiated walking capacity at the high end and also identified a subgroup with limitations. The self-report and performance measures were significantly, but weakly, correlated (0.13‐0.3...
280 Citations Source Cite
Published on Oct 1, 1994in Journal of the American Geriatrics Society 4.16
Stephen R. Lord90
Estimated H-index: 90
(Prince of Wales Medical Research Institute),
John A. Ward12
Estimated H-index: 12
+ 1 AuthorsKaarin J. Anstey57
Estimated H-index: 57
OBJECTIVE: To determine the prevalence of impaired vision, peripheral sensation, lower limb muscle strength, reaction time, and balance in a large community-dwelling population of women aged 65 years and over, and to determine whether impaired performances in these tests are associated with falls. DESIGN: One-year prospective study. SETTING: Conducted as part of the Randwick Falls and Fractures Study, in Sydney, Australia. PARTICIPANTS: Four hundred fourteen women aged 65 to 99 years (mean age 7...
623 Citations Source Cite
Taina Rantanen48
Estimated H-index: 48
(University of Jyväskylä)
The aims of this review are to address (1) the role of muscle strength in the disablement process and (2) muscle strength as a predictor of length of life using data from prospective studies. Functional limitations, such as slow walking speed, predispose older people to disabilities. How much strength is needed for daily motor tasks such as walking varies according to other impairments present. For example, when postural balance is good, only minimum amount of strength is needed for walking. How...
207 Citations Source Cite
Published on Jun 1, 1991in Journal of the American Geriatrics Society 4.16
Richard L. Reed25
Estimated H-index: 25
(University of Arizona),
Lori Pearlmutter4
Estimated H-index: 4
(American Physical Therapy Association)
+ 2 AuthorsArshag D. Mooradian50
Estimated H-index: 50
(University of Arizona)
To determine the extent that muscle mass is predictive of muscle strength in the elderly, anthropomorphic estimates of muscle area and impedance measurements of muscle mass and peak isometric muscle strength were obtained in a relatively healthy older population over 65 years of age (mean age = 71.7; n = 218). Midarm muscle area correlated strongly with upper arm strength (r = 0.68, P < 0.0001) while midthigh muscle area had a much lower correlation with thigh muscle strength (r = 0.29, P < 0.00...
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Published on Feb 10, 1999in JAMA 47.66
Taina Rantanen48
Estimated H-index: 48
,
Jack M. Guralnik69
Estimated H-index: 69
+ 4 AuthorsLon R. White76
Estimated H-index: 76
ContextPoor muscle strength, functional limitations, and disability often coexist, but whether muscle strength during midlife predicts old age functional ability is not known.ObjectiveTo determine whether hand grip strength measured during midlife predicts old age functional limitations and disability in initially healthy men.Design and SettingA 25-year prospective cohort study, the Honolulu Heart Program, which began in 1965 among Japanese-American men living on Oahu, Hawaii.ParticipantsA total...
899 Citations Source Cite
Cited By1157
Published on Jan 1, 2014
Peter Francis4
Estimated H-index: 4
Published on Jan 1, 2013
Eugene J. Pietzak5
Estimated H-index: 5
(Hospital of the University of Pennsylvania),
Thomas J. Guzzo27
Estimated H-index: 27
(Hospital of the University of Pennsylvania)
The elderly population is the fastest growing age group in the United States. This will likely result in more elderly patients presenting for urologic surgery annually. When considering a patient for surgery, age alone should not be a contraindication. The decision on surgery should be individualized for the patient and their problem.
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Published on Mar 20, 2015in Nervenarzt 0.74
Walter Maetzler3
Estimated H-index: 3
,
Michael Drey14
Estimated H-index: 14
(Ludwig Maximilian University of Munich),
Andreas H. Jacobs47
Estimated H-index: 47
Sarkopenie und Frailty sind haufige, alltagsrelevante und lebensqualitatbeeinflussende geriatrische Syndrome. Uber das Vorkommen dieser Syndrome bei und den Einfluss dieser Syndrome auf altersassoziierte/n neurologische/n Erkrankungen wie Parkinson-, Alzheimer-Erkrankung und Schlaganfall ist wenig bekannt. Dieser Ubersichtsartikel stellt die Konzepte von Sarkopenie und Frailty vor, arbeitet die Relevanz der Symptome beim alten Menschen heraus und stellt dann die bis dato vorliegende Literatur zu...
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This thesis investigated the role of O\(_2\)-dependent substances in mediating the vasodilatation seen following exercise (post-exercise hyperaemia) and in fatigue development. Additionally we compared young and old subjects to investigate the effects of ageing in both of these phenomena. Breathing supplementary 40% O\(_2\) during handgrip exercise at 50% of maximum voluntary contraction had no effect of the magnitude of post-exercise hyperaemia compared to air breathing control. Furthermore, as...
Published on Jan 1, 2008
Erin Louise Gemmill1
Estimated H-index: 1
Accelerometers are reliable, valid, and versatile tools for measuring physical activity for research studies. However, compliance to protocols of accelerometer use by participants of research studies is crucial in order to ensure the most accurate measure of their physical activity. It is possible that aging effects on physical and cognitive health will limit the ability of an older adult to be compliant with wearing an accelerometer. Unfortunately, research investigations into the factors that ...
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Published on Jun 6, 2012in Herz 0.94
Typ-2-Diabetiker mit Herzinsuffizienz stellen eine immer groser werdende Patientengruppe dar. Nachweislich profitieren diese Patienten von korperlichem Training. Die in zahlreichen Studien gezeigten positiven Veranderungen in Bezug auf kardiovaskulare Risikofaktoren, Morbiditat und Mortalitat lassen sich nur durch langfristige Trainingsprogramme in Form einer Kombination aus Ausdauer- und Krafttraining erzielen. Dieses wirksame und kostengunstige Therapeutikum sollte moglichst vielen Patienten a...
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Published on Jan 1, 2011in Der Internist 0.44
Published on Jul 1, 2011
Fabian Guenzkofer3
Estimated H-index: 3
(Technische Universität München),
Florian Engstler4
Estimated H-index: 4
(Technische Universität München)
+ 1 AuthorsKlaus Bengler19
Estimated H-index: 19
(Technische Universität München)
The purpose of this experiment is to obtain isometric knee extension and flexion joint torque - joint angle functions considering necessary biomechanical aspects. In order to examine gender and age effects four different subject groups (10 young males and females, 8 old males and females) were used. Age and gender had a significant influence for both force directions. Not only different maximum values but also different curve shapes were identified for different age groups. Additionally the hip ...
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Published on Jan 1, 2014
Edgar Pierluissi1
Estimated H-index: 1
(San Francisco General Hospital),
Deborah C. Francis1
Estimated H-index: 1
(Kaiser Permanente),
Kenneth E. Covinsky66
Estimated H-index: 66
(University of California, San Francisco)
Hospitalization is a sentinel event in the life of an older person. Despite appropriate treatment for the reason for admission to the hospital, older adults suffer high rates of hospitalization-associated disability (HAD) and other complications such as delirium, falls, and pressure ulcers with long-term consequences. HAD carries a poor prognosis for further disability, nursing home placement, and increased mortality and confers significant costs to patients, families, and society. Patients at r...
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