Roscovitine Inhibits CaV3.1 (T-Type) Channels by Preferentially Affecting Closed-State Inactivation
Volume: 340, Issue: 2, Pages: 463 - 472
Published: Nov 16, 2011
Abstract
T-type calcium channels (CaV3) play an important role in many physiological and pathological processes, including cancerogenesis. CaV3 channel blockers have been proposed as potential cancer treatments. Roscovitine, a trisubstituted purine, is a cyclin-dependent kinase (CDK) inhibitor that is currently undergoing phase II clinical trials as an anticancer drug and has been shown to affect calcium and potassium channel...
Paper Details
Title
Roscovitine Inhibits CaV3.1 (T-Type) Channels by Preferentially Affecting Closed-State Inactivation
Published Date
Nov 16, 2011
Volume
340
Issue
2
Pages
463 - 472
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