Dose-dependent teratogenicity of valproate in mono- and polytherapy
Abstract
To assess the risk of major congenital malformations (MCMs) in association with maternal use of valproic acid (VPA) in monotherapy or adjunctive therapy, and its relationship with dose.The analysis was based on prospectively acquired data from EURAP, a registry enrolling women treated with antiepileptic drugs (AEDs) in early pregnancy, in which the primary outcome is presence of MCMs at 1 year after birth. Exposure was defined as type and dose...
Paper Details
Title
Dose-dependent teratogenicity of valproate in mono- and polytherapy
Published Date
Sep 8, 2015
Journal
Volume
85
Issue
10
Pages
866 - 872
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