Generation and characterization of osteochondral grafts with human nasal chondrocytes

We investigated whether nasal chondrocytes (NC) can be used to generate composite constructs with properties necessary for the repair of osteochondral (OC) lesions, namely maturation, integration and capacity to recover from inflammatory burst. OC grafts were fabricated by combining engineered cartilage tissues (generated by culturing NC or articular chondrocytes – AC – onto Chondro‐Gide ® matrices) with devitalized spongiosa cylinders (Tutobone...