Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation
Abstract
The human cytomegalovirus glycoprotein US2 induces dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol and targets them for proteasomal degradation. Signal peptide peptidase (SPP) has been shown to be integral for US2-induced dislocation of MHC class I heavy chains although its mechanism of action remains poorly understood. Here, we show that knockdown of protein disulphide isomerase (PDI) by RNA-mediated...
Paper Details
Title
Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation
Published Date
Nov 26, 2009
Journal
Volume
29
Issue
2
Pages
363 - 375
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