Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor
Abstract
Background and aims: The exact nature of the epithelial barrier defect in Crohn’s disease remains to be elucidated. Previously we showed increased permeability to proteins in ileal Crohn’s disease. Our aims were to study if this barrier defect (a) involves endocytotic uptake of antigens and (b) is related to low grade inflammation not detectable by histology. Methods: Macroscopically normal segments of distal ileum of Crohn’s disease patients (n...
Paper Details
Title
Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor
Published Date
Dec 1, 2004
Journal
Volume
53
Issue
12
Pages
1817 - 1824
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