Impaired Learning and Motor Behavior in Heterozygous Pafah1b1 (Lis1) Mutant Mice
Abstract
Heterozygous mutation or deletion of Pafab1b1 (LIS1) in humans is associated with syndromes with type 1 lissencephaly, a severe brain developmental disorder resulting from abnormal neuronal migration. We have created Lis1 heterozygous mutant mice by gene targeting. Heterozygous mutant mice are viable and fertile, but display global organizational brain defects as a result of impaired neuronal migration. To assess the functional impact of the...
Paper Details
Title
Impaired Learning and Motor Behavior in Heterozygous Pafah1b1 (Lis1) Mutant Mice
Published Date
Sep 1, 1999
Journal
Volume
6
Issue
5
Pages
521 - 537
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