Transient Activation of the ALT Pathway in Human Primary Fibroblasts Exposed to High-LET Radiation
Abstract
It is well established that high-LET radiations efficiently induce chromosome aberrations. However, data on the effect of protons on telomere maintenance, as involved in genomic stability, are scarce and contradictory. Here we demonstrate that high-LET protons induce telomere lengthening in human primary fibroblasts and that this elongation does not involve the telomerase enzyme, supporting the hypothesis that high-LET radiations are able to...
Paper Details
Title
Transient Activation of the ALT Pathway in Human Primary Fibroblasts Exposed to High-LET Radiation
Published Date
Nov 1, 2010
Journal
Volume
174
Issue
5
Pages
539 - 549
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