Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity
Abstract
Excessive accumulation of amyloid β-peptide (Aβ) plays an early and critical role in synapse and neuronal loss in Alzheimer's Disease (AD). Increased oxidative stress is one of the mechanisms whereby Aβ induces neuronal death. Given the lessened susceptibility to oxidative stress exhibited by mice lacking p66Shc, we investigated the role of p66Shc in Aβ toxicity. Treatment of cells and primary neuronal cultures with Aβ caused apoptotic death and...
Paper Details
Title
Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity
Published Date
Apr 25, 2005
Journal
Volume
169
Issue
2
Pages
331 - 339
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