Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

Volume: 307, Issue: 3
Published: Aug 1, 2014
Abstract
Adipose tissue expansion during obesity is associated with increased macrophage infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. Identification of the major factors that mediate detrimental effects of macrophages on adipocytes may offer potential therapeutic targets. IL-1β, a proinflammatory cytokine, is suggested to be involved in the development...
Paper Details
Title
Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes
Published Date
Aug 1, 2014
Volume
307
Issue
3
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