Key determinants of target DNA recognition by retroviral intasomes
Abstract
Retroviral integration favors weakly conserved palindrome sequences at the sites of viral DNA joining and generates a short (4-6 bp) duplication of host DNA flanking the provirus. We previously determined two key parameters that underlie the target DNA preference for prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1) integration: flexible pyrimidine (Y)/purine (R) dinucleotide steps at the centers of the integration...
Paper Details
Title
Key determinants of target DNA recognition by retroviral intasomes
Published Date
Apr 30, 2015
Journal
Volume
12
Issue
1
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