Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation
Abstract
We have measured the expression of T-type Ca2+ channel mRNA in breast cancer cell lines (MCF-7 (ERα+) using Western blot and quantitative real-time PCR (Q-RT-PCR). These results revealed that the MCF-7 cells express both α1G and α1H isoforms of T-type Ca2+ channels. In order to further clarify the role of T-type Ca2+ channels in proliferation, we tested the effects of a selective T-type Ca2+ channel inhibitor NNC-55-0396 on cellular...
Paper Details
Title
Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation
Published Date
Aug 1, 2008
Journal
Volume
267
Issue
1
Pages
116 - 124
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