Genomewide Association Analysis Followed by a Replication Study Implicates a Novel Candidate Gene for Neuroticism

Context

Neuroticism is a trait that reflects a tendency toward negative mood states. It has long been linked to internalizing psychiatric conditions, such as anxiety and depression, and it accounts for much of the substantial comorbidity seen between these disorders.

Objective

To identify common genetic variants that affect neuroticism to better understand (the comorbidity between) a broad range of psychiatric disorders and to...