In vivo anticancer activity of rhomboidal Pt(II) metallacycles

Significance The design of new antitumor agents and the search for delivery vehicles for existing drugs are two problems in cancer therapy that are often solved separately. Drug delivery vehicles are typically nontherapeutic, leaving antitumor effects exclusively to the encapsulated drug. However, the combination of an anticancer drug and a delivery vehicle with inherent antitumor properties could produce a synergistic effect, thus enhancing the...