Variability of average SUV from several hottest voxels is lower than that of SUVmax and SUVpeak

To assess variability of the average standard uptake value (SUV) computed by varying the number of hottest voxels within an 18F-fluorodeoxyglucose (18F-FDG)-positive lesion. This SUV metric was compared with the maximal SUV (SUVmax: the hottest voxel) and peak SUV (SUVpeak: SUVmax and its 26 neighbouring voxels). Twelve lung cancer patients (20 lesions) were analysed using PET dynamic acquisition involving ten successive 2.5-min frames. In each...