ERBB 4 confers metastatic capacity in Ewing sarcoma

Metastatic spread is the single‐most powerful predictor of poor outcome in Ewing sarcoma (ES). Therefore targeting pathways that drive metastasis has tremendous potential to reduce the burden of disease in ES. We previously showed that activation of the ERBB4 tyrosine kinase suppresses anoikis , or detachment‐induced cell death, and induces chemoresistance in ES cell lines in vitro . We now show that ERBB4 is transcriptionally overexpressed in...