Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms.
Published: Jan 15, 2013
Abstract
Pancreatic β-cells regulate glucose homeostasis by secreting insulin in response to glucose elevation and G protein-coupled receptor (GPCR) activation. Neuropeptide Y (NPY) and somatostatin (SST) attenuate insulin secretion through G(i) activation of Y(1) and SSTR(1&5) receptors, respectively. The downstream pathways altered by NPY and SST are poorly understood. Thus, we investigated these underlying mechanisms. NPY and SST increase cellular...
Paper Details
Title
Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms.
Published Date
Jan 15, 2013
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