High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes
Abstract
Using high-throughput sequencing, we devised a technique to determine the insertion sites of virtually all members of the human-specific L1 retrotransposon family in any human genome. Using diagnostic nucleotides, we were able to locate the approximately 800 L1Hs copies corresponding specifically to the pre-Ta, Ta-0, and Ta-1 L1Hs subfamilies, with over 90% of sequenced reads corresponding to human-specific elements. We find that any two...
Paper Details
Title
High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes
Published Date
May 20, 2010
Journal
Volume
20
Issue
9
Pages
1262 - 1270
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