Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys
Abstract
Given concern about potential embryo-fetal harm following seminal exposure to drugs with teratogenic potential, pharmaceutical companies use theoretical calculations to estimate seminal concentrations, maternal exposure, and distribution across the placenta to the embryo-fetal compartment for risk assessment. However, it is plausible that there are additional mechanisms whereby the conceptus is exposed. In order to determine if theoretical...
Paper Details
Title
Evaluation of early fetal exposure to vaginally-administered metronidazole in pregnant cynomolgus monkeys
Published Date
Jan 1, 2016
Journal
Volume
59
Pages
17 - 21
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Notes
History